While the ‘Hymn For The Weekend’ hitmakers are up for Best Live, Best Video for ‘Up&Up’, Best Rock and Best Local Act in the UK and Ireland.
Pop trio Years & Years have already been chosen as the receivers of the Best UK and Ireland Act, which saw them nominated against Adele, Coldplay, Little Mix and Zayn Malik.
And Scottish DJ Calvin Harris has received a nod for Best Male.
In the Best Push list British rockers Blossoms, Jack Garratt and Anne-Marie will go up against international acts Bebe Rexha, Charlie Puth, Alessia Cara, DNCE, Dua Lipa, Elle King, Halsey, Jonas Blue and Lukas Graham.
Duran Duran, Ellie Goulding, Jess Glynne and Tinie Tempah will also battle it out for BEST WORLD STAGE .
The artists with the biggest nominations are Justin Bieber and Beyonce, who will go head to head in the Best Fan category.
The 22-year-old pop hunk is also up for Best Song for ‘Sorry’, Best Male and Best Local Act in Canada.
The ‘Lemonade’ singer is up for Best Video for her comeback single ‘Formation’, Best Female, Best Live and Best Local Act [US].
Bieber will battle it out with Calvin Harris, Drake, Shawn Mendes and The Weeknd for Best Male.
While Beyonce has stiff competition for Best Female in the form of Adele, Lady Gaga, Rihanna and Sia.
Rihanna and Drake have received three nominations in total.
The ‘Love On The Brain’ hitmaker and ‘Hotline Bling’ rapper received a nod each for their song ‘Work’.
The Bajan beauty will also compete for Best Female and Best Pop while the 29-year-old star is up for Best Male and Best Hip Hop.
And this year features the hottest Best New Artist category to date, with Bebe Rexha, DNCE, Lukas Graham, The Chainsmokers and Zara Larsson all up for gongs.
Best Rock contenders also include Green Day, Metallica,
Twenty one pilots will also compete for Best Alternative alongside Kings of Leon, Radiohead, Tame Impala and The 1975.
And Best Hip Hop sees Future, G-Eazy ad Wiz Khalifa up against Kanye West.
The winners will be revealed at a star-studded ceremony at Ahoy Rotterdam in Rotterdam, Netherlands on November 6.